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World J Pediatr
Pharmacokinetic Profile: Plasma half-life: approximately 2 hours Selective GHS-R1a agonism without significant ACTH/cortisol stimulation Minimal desensitization with repeated administration in research models concentration-dependent GH release with peak levels 30-60 minutes post-administration Tesamorelin Component Molecular Properties: CAS Number: 218949-48-5 (as acetate salt: 804475-66-9) Molecular Weight: 5,135.87 Da (free peptide), 5,723.93 Da (hexaacetate salt) Molecular Formula: CHNOS Sequence: First 44 amino acids of human GHRH with trans-3-hexenoyl modification at N-terminus Classification: Stabilized GHRH analog Receptor Target: GHRH receptor (GHRH-R) Tesamorelin incorporates a trans-3-hexenoyl group at the N-terminus, a modification that significantly enhances metabolic stability compared to native GHRH
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